The work includes the analysis of polymorphic variants of nine selected risk-candidate genes (ACE, angiotensinogen, Apo E, LRP1, E-selectin, Factor V, G protein and p22 phox), which be associated with the emergence of cardiovascular disease, in a group of blood donor of the central German region Halle-Merseburg and Bitterfeld. The analysis was carried out according to age and gender and included the comparison of own results with those of international publications. After genotyping of 442 blood samples from healthy blood donors (271 men, 171 women) of the University Blood Transfusion Service Halle and molecular genetic studies using PCR and RFLP techniques, several age-and sex-dependent distribution differences were detected in the subjects, which indicate selection effects in the blood donor pool. Notable differences were found in an international comparison with Japanese populations. In four of the investigated polymorphisms the least number of carriers of the gene variants considered to be conspicuous was found in Japanese.