We identified the phenotypic subtypes of tumor infiltrating lymphocytes from patients with kidney tumors. The complete examination group contained 119 patients (92 cases of clear cell carcinoma). After preparing leukocytes out of the fresh tumor tissues, we employed immune fluorescence stainings with a combination of different monoclonal antibodies followed by 4-color flow cytometry. All results were evaluated statistically by univariate and multivariate analysis models. For the histology “clear cell carcinoma“ and high intratumoral percentages of CXCR3+ T cells or HLA-DR+ T cells, a higher probability of surviving was found. Furthermore, high intratumoral amounts of NK cells were connected with a lower mortality risk in clear cell carcinoma. Our data give hints that lymphocytic marker molecules reflect the special conditions of tumor microenvironment. Investigating the properties of intratumoral lymphocytic subpopulations can be helpful for the valuation of patient’s prognosis. |