The possible effects on the renal physiology during a laparoscopic procedure according to the established pneumoperitoneum is well known. To date, still largely unlit is how this phenomenon affects a renal transplant. According to this context, the aim of this study was to describe the influence of an laparoscopic operation on a renal transplant. More precisely on the function, the organ integrity and the Immunology. Recognized parameters, the levels of functionality, organ integrity and the immune status of renal transplant representing were evaluated from the serum and urine of 29 patients in the postoperative period after various laparoscopic procedures. The filtration function of the kidney transplant remained unaffected after laparoscopic surgery (no significant alteration of creatinine). Rather postoperatively, a significant decrease of cystatin C levels were objectified. Regarding the organ integrity, there was no indication of any significant disturbance of the structural or functional integrity of the glomerular and tubular cell structures of the kidney transplant after the laparoscopic procedure. Moreover, at no time, the typical pattern of an acute rejection was objectified. The local immune status concerning, there was neither a significant activation, yet found himself a typical acute rejection and acute phase protein interleukin - excretion patterns. The moderate systemic inflammatory response to the trauma "laparoscopy", affirmed in comparison to previous work, again the minimal invasiveness of this surgical procedure.In conclusion, our findings suggest that laparoscopic procedures even or especially in patients with renal transplant can be considered safe and beneficial, and that notedly this particular group of patients may benefit from this surgical procedure.