The present study examined the impact of the ubiquitous EDCs DEHP and PCB (101 + 118) on early embryonic development. Environmental and higher doses were analyzed for single and combination effects. For this, two murine stem cell models (P19-ECC + C3H10T1/2) were used. The results of this study show a DEHP-induced fetal (mis-) programming, which altered the metabolism and function of cardiomyogenic differentiated P19-ECC at the end of culture. PCB exposure altered the expression of molecular markers during the early stages of differentiation. The combined exposure with DEHP+PCB of P19 ECC resulted in changes of the expression of metabolic and methylation-specific markers mainly in the lowest concentration group, up to the final stages of differentiation. A DEHP + PCB-induced fetal programming is thereby feasible. A DEHP and / or PCB exposure of C3H10T1/2-cells led to changes in the profile of protein expression of differentiated C3H10T1/2 derived adipocytes. It can therefore be assumed that DEHP and / or PCBs are also able to deregulate adipogenesis.