Over the past years the 5-year survival rate of oral squamous cell carcinoma has not improved substantially despite of the introduction of new diagnostic and therapeutic measures. Using immunohistochemical staining of 75 fixed paraffin sections of oral squamous cell carcinoma the expression of tumor-related proteins survivin, vascular endothelial growth factor (VEGF-C) and carbonic anhydrase IX (CAIX) has been studied. The results has been correlated with clinicopathological data and 5-year survival rate to investigate the influence of the three descripted proteins onto prognosis of the disease. Singular observation of the three proteins revealed no significant increased risk of conditional tumor-decease. However, the combined analysis of all three proteins was able to demonstrate a significant 5.1-fold increased risk of tumor-associated decease, when survivin and CAIX were strongly expressed, while VEGF-C showed weak expression.