In this study we tried by creating a hybridsystem, consisting of porous polyethylene (Medpor®) and autologous chondrocytes, to minimize implantation complications and to maximize the integration into surrounding tissue. We took chondrocytes from the concha of 75 guineapigs and seeded polyethylene (PE)- respectively surface-modificated PE-samples. One seeded PE-sample was implanted into the ear of the animal, another one with the same modifications but unseeded was implanted into the contralateral ear. After 1, 6, and 12 months we removed these samples plus surrounding tissue. The microscopic examination showed especially in the 6- and 12- months samples enormous differences. The pre-seeded specimens showed a good growth of neo-cartilage and a better integration into surrounding tissue. This study shows that a bioshell of autologous chondrocytes around porous polyethylene results in a lower foreign body reaction, a better integration into surrounding tissue and a good growth of neo-cartilage.