To analyze the quality of life of lung cancer patients treated with radiotherapy forty five patients were interviewed in the department of Radiation Oncology of a university hospital. The EORTC questionnaires QLQ-C 30 and QLQ-LC 13 were used. Thirty-four males and 11 females (mean age: 66 years) were assessed. Seven patients had small cell lung cancer and 38 had non-small cell lung cancer. The results showed no significant difference in quality of life before, after and 3 months after radiotherapy. The function scales present a worsening of physical function after radiotherapy and role function after three months. The tumor-associated dyspnea was significantly reduced after radiotherapy but in combination with increased dysphagia. In the sub-group analysis we found significantly differences between females versus males and between UICC-stage IIIA-B versus stage IV. Pre-treatment pulmonary function and patient’s age had no influence on quality of life outcomes.