Background: ERCC1 is a nuclease, which plays a key role in the nucleotide-excision-repair-mechanism. In several studies ERCC1 could be identified as a predictive marker for a platinum-based chemotherapy. The objective of this dissertation is to examine, if there are differences in the distribution of ERCC1 on prognostic relevant factors of lung cancer. Methods: The objects of this study were 153 patients, who had a lung cancer extirpation in the years 2008 and 2009. Following the standard procedure, the resected tumor has been tested for ERCC1 immunohistochemically. The information about the prognostic relevant factors was found in the patient files. For the distribution analysis, the absolute and relative frequency, including the 95% confidence intervals, were used. Results: It could be shown that with the squamous cell carcinomas have the highest rate of ERCC1-positive findings in comparison with other tumor histologies. Additionally the number of ERCC1-positive findings decreased from stage I to stage IIIA. Only minor differences were found in the smoking status, sex and age. Conclusion: Due to the low case counts, only trends can be shown. In conclusion, the evidence is not sufficient, however, to ascertain that there are irrefutable differences in the distribution of ERCC1 on prognostic relevant factors of lung cancer.