This study rests on three regional case studies. Using the example of the West-Indian Palan-puri community which has specialised in trading diamonds, it shows that transnational entre-preneurs can significantly contribute to transferring knowledge over great distances and thus be considered as an important element of knowledge-based regional development. Global pipelines developed by transnational entrepreneurs can support the outflow of knowledge about markets and technologies from an existing cluster. When applied to a different regional context, this knowledge may prove supportive to the formation of new clusters. These devel-opments need not necessarily result in locations that complement each other, as suggested in the literature. Rather, the new centres can enter into competition with the established ones. In the long-run, this can result in numerous relocations on a global scale.