The aim of the present study was to test the sufficent effectiveness of common disinfection procedures (normally used for impression material and dental instruments) on dental polymethyl methacrylate (PMMA). Already accomplished tests in previous studies, that determine if disinfection has an influence of selected mechanical properties of PMMA, should be included to make a final recommendation. Material and methods: Specimens of PalaXpress, Orthocryl and Paladon 65 were prepared and disinfected with Stammopur DR, Mucalgin and Impresept. C.albicans, P.aeruginosa and S. aureus were used for contamination. The reduction factors were calculated. Results: After incubation no grown colonies could be found on the disinfected specimens. The reduction factors achieved were far beyond the required limits according to DGHM and VAH, a reduction of at least 4 log-ranges (fungi) and 5 log-ranges (bacteria). Other studies have shown significant differences for selected mechanical properties of PX and OC resulting from using Stammopur DR. Conclusion: According to the present study each disinfection procedure has been effective on selected dental PMMA. Conclusion: Only Impresept can be recomannded regarding to effectiveness, influence of physical prosperities and ease-of-use. A product-specific recommendation regarding to the disinfectant and the dental PMMA would be desirable.