The objective of this in-vitro-study was the comparison of CoCr- and ZrO2-crowns with pressed or layered veneer. On 80 metal dies, 40 cervical shortened CoCr- and ZrO2-frameworks were fabricated using CAD/CAM-technology, 30 frameworks of each material were veneered with different pressed ceramics of tooth shade A3, 10 frameworks were veneered with layered ceramics and served as reference. After cementation, vertical marginal gap measurement using light microscope and digital tooth shade measurement were undertaken. Subsequently, half of the crowns made of one material combination underwent cyclic mechanical loading and thermal undulation. Finally, fracture strength was determined by pressure test and fracture mode was assessed descriptively.With both veneering technologies comparable acceptable clinical results were achieved concerning marginal discrepancy and fracture strength. With regard to color reproduction, the layering techniques provided to be superior to the pressing technique. Corrective actions seemed to improve the pressed ceramics resistance against thermal undulation.