Malignant melanoma accounts for 90% of skin-cancer mortality and the incidence is rising continously. Several histological parameters and classifications based on sentinel lymph nodes (SLN) have been postulated that predict prognosis. We evaluated the prognostic relevance of six histological SLN-parameters with respect to local recurrence-free survival (LRFS) and disease-free survival (DFS). Between 2004 and 2012, 346 consecutive patients with primary melanoma underwent SLN-Biopsy. Multivariabel Cox regression was used to assess the prognostic value of: SLN-status, S-classification, Dewar and Rotterdam criteria, intra- and extracapsular tumor spread (ECS).86 patients (24.9%) showed micrometastases. Highly predictive markers on both outcomes were: SLN-status, S III, Dewar IV-V, Rotterdam III, extracapsular spread. Capsular infiltration predominately reflects locoregional spread. An increment in tumorsize and -penetration depthby 500µM was associated with a mildly increased risk of tumor spread and helps risk prediction in low risk patients. Yet, no single parameter reflects the anatomy of tumor invasion and the prognosis entirely.