Work-related cooperation and communication (coopcomm) is a common demand on employees in the context of their routine activities, while at the same time, it is frequently a central topic in psychological risk analysis inventories. However, empirical studies on the impact of this occupational characteristic are lacking. This thesis examines the relationship between coopcomm and medium-term psychological strain in a population of working individuals. Coopcomm was investigated by means of questionnaires as well as observational studies. Two aspects of coopcomm – the presence of coop-hindrances and the experience of a low coopcomm quality – were related to psychological strain, e.g., depressiveness and vital exhaustion. The work-related demand for coopcomm alone did not exhibit a relationship with the employee strain under investigation. The results are discussed in light of their relevance in the application of occupational risk analyses and the derivation of work design policies.