In this study, synovial and leiomyosarcomas were examined by immunohistochemistry. We were interested if survivin detected by immunohistochemistry has prognostic relevance especially for patients with the two soft tissue sarcoma entities. Survivin, a member of the inhibitor of apoptosis-protein family suppresses apoptosis and regulates cell division. It is strongly overexpressed in the vast majority of cancers. We were also interested if the hypoxia markers carboanhydrase9 and osteopontin detected by immunohistochemistry has prognostic relevance in both entities. Tumors of leiomyosarcoma (n = 24) and synovial sarcoma patients (n = 26) were investigated for their expression of survivin, carboanhydrase9 and osteopontin by immunohistochemistry. The expression of theproteins was assessed in tumor cells using an immunoreactive scoring system (IRS). The Statistical analysis was performed by multivariate Cox-regression analysis. Survivin protein expression in the cytoplasma and in the nucleus detected by immunohistochemistry is significantly associated with prognosis of leiomyosarcoma and synovial sarcoma patients. Furthermore, a significant association between the protein expression of CA9 and OPN and the tumor-associated survival for Synovialsarkome, could be shown.