In catheter-based aortic valve implantation (TAVI) a minimally surgical approach through the ascending aorta (transaortic) has been successfully applied in addition to the transfemoral approach. This work presents a retrospective analysis of 153 patients with TAVI (transfemoral 75, transaortic 78, 2010 to 2013) at the University Hospital Halle. Between the access routes no significant difference in implantation outcome or mortality has been found. The complications are quite comparable, but there is an advantage of transaortic access with regard to vascular complications. Independent predictors of increased mortality are diabetes mellitus, elevated brain natriuretic peptide (BNP) levels, acute renal failure, bleeding complications and post interventional aortic regurgitation. To evaluate the perioperative risk in patients, the STS score shows the most appropriate result, while the AKL score shows a good discrimination of 1-year mortality.