High blood pressure is one of the leading risk factors for cardiovascular diseases and the major contributor to stroke. Different studies suggest relevant differences in the regional prevalence of hypertension within Germany. First analyses of the CARLA-study show a high prevalence of cardiovascular risk factors in regional comparison. The age adjusted prevalence of hypertension for Baseline were 74,3% (95% CI 68,6- 80,1) in men and 68,4% (62,6-74,2) in women. In national and international comparison the prevalence of hypertension in the CARLA-study is increased. Prevention of hypertension should be provided comprehensive. Thus, many associated and consequent diseases can be minimized by development and healthcare costs can be reduced.