The three RNA binding proteins of the IGF2BP family play an important role in posttranscriptional gene regulation. Except IGF2BP2 all members show a oncofetal expression pattern. In genome wide association studies IGF2BP2 is linked to type 2 diabetes mellitus and therefore glucose metabolism. The aim of this thesis was to analyze the functions of the IGF2BPs in healthy adult organisms. Therefore, 2 different transgenic mouse models were created overexpressing the human IGF2BPs constitutively (liver specific and ubiquitous). A liver specific overexpression of IGF2BP1/2/3 lead to little effects, whereas mice with ubiquitously overexpressed IGF2BP2 showed a higher body weight and increased size. Also, these mice showed better glucose tolerance. Upon high fat diet the animals had a higher insulin sensitivity, showed lower blood glucose levelsand lowerweight gain. Taken together IGF2BP2 modulates glucose and fat metabolism and can play a regulating role in growth.