Zinc plays as cofactor of metalloproteins an important role in biological systems. In spite of the biological value high concentrations of zinc are toxic for the cell and a balance between uptake and efflux is the logical consequence. In this work the regulators for zinc uptake and efflux from the Fur- and MerR-family were identified in the β-proteobacterium Cupriavidus metallidurans, which is adapted on heavy metal-contaminated environments. The zinc uptake regulator (FurC) controls gene expression for the transport system ZupT, which plays under the seven secondary uptake systems an essential role for zinc acquisition under metal limiting conditions. In addition FurC controls gene expression for putative paralogs of zinc containing enzymes and chaperons (cobW) by binding a consensus sequence in three further promotor regions. Furthermore the gene product Rmet3456/ ZntR acts as activator for the zinc induced efflux system ZntA. Both FurC and Rmet3456 form the regulatory network for the zinc homeostasis in C. metallidurans.