For years the diagnostic value of exercise electrocardiogram has been discussed controversially, especially as it often leads to false-positive results in women. In 2010, Kronander et al. realized that the ST-Segment-/Heart Rate-Hysteresis (ST-/HR-Hysteresis), developed by Lehtinen and colleagues, offers the most accurate and gender indifferent identification of patients with coronary artery disease. The aim of this prospective study was to verify this method on patients of the university hospital of Halle (Saale). In addition, the diagnostic value of conventional ST-segment analysis and ST-/HR-Hysteresis was analyzed. Based on our study results we can say that the ST-/HR-Hysteresis is not suitable as a diagnostic marker of coronary heart disease, which is also reflected in the ROC-Analysis. The examination of precordial lead V5 showed an area under the curve (AUC) of only 63,4 %. Moreover, the results of conventional ST-segment analysis suggest a low reliability of exercise electrocardiogram, which is generally known.