Tripartite-motif- proteins (TRIMs) are characterized by a conserved structure of RING-domain, B-box- domain and coiled- coil region and are regarded as putative E3 ligases while ubiquitination. Trim23 and Trim7, two of more than 70 known TRIM family members, are chosen to characterize their role in the early embryonic development of Xenopus laevis. “Whole-mount” in situ hybridization and PCR were used for expression profiling. Both Trims are expressed maternally, in eye vesicles and in caudal parts of the neural tube. Trim23 seems to play a role in the cellular traffic processes because of its C-terminal ARD1 (ADP-ribosylation factor domain protein 1) domain which has a putative GTPase function. Trim7 interacts with glycogenin as GNIP 1 (glycogenin interaction protein 1) and seems to be a progenitor in the development of malignant neoplasms.