The endometrial cancer (EC) is the most common cancer of the female genital in the western world. One differentiates between 2 subtypes: type I and type II carcinomas. The type I EC is usually associated with a very good prognosis, but unexpectedly bad progress is observed. A further contribution to the elucidation of possible genetic predictors of the EC should be made with this work. Therefore, the influence of four single nucleotide polymorphisms of the p53-MDM2 / 4 regulatory network (MDM2 SNP 309, MDM4 SNP 31826 and 34091, p53 Codon72 SNP) with regard to tumor biology was investigated for disease risk, diagnosis age and survival of 170 EC patients examined. Finally, a significant effect of the homozygous minor alleles of the MDM4 polymorphisms on the age of diagnosis and the survival of the type I-EC patients could be shown. Furthermore, an insignificant, life-prolonging effect of the homozygous proline variant of the p53 Codon72 SNP could be demonstrated. On the basis of this collective, no influence of the MDM2 SNP 309 on the EC could be determined.