It was investigated whether an operative aggressiveness increasing over time led to improving prognoses. 2725 tumors (squamous cell carcinomas of oral mucosa, lips and facial skin, salivary gland tumors, sarcomas, melanomas, basal cell carcinomas) were histologically reclassified, their therapy was analyzed and over 25 years covered by controls. Long –term analyses were illustrated by the product limit method (Kaplan Meier) for survival and freedom of the tumor. An increase in the number of oncological patients as well as changes of structure and therapeutic concepts took place. Within each entity and depending on the R1 status analyses resulted in groups with identical prognosis. Within these groups, over time the improvement of survival rates was not as good as expected. This was due to an unexpectedly low influence on regional metastases. Consequently, modifications for the lymphadenectomy are discussed. In the course of time the quality of life becomes better through use of primary reconstructive surgery.