Local inflammatory processes impair the skin barrier and lead to dry skin. Salvia officinalis L. contains antioxidant and anti-inflammatory ingredients. This randomized, double-blind, vehicle controlled study analyzed the effect of topical applied sage extract on the barrier function of human skin. Fifteen study participants were treated with 0.5% SLS in defined skin areas to induce a skin barrier disruption. Then the preparation (hydrophilic base with 3%, 12%, 25% sage extract, lipophilic base with 1%, 4%, 8% sage extract) were applied every twelve hours over five days. The main active substances were rosmarinic acid and luteolin-7-glucoside. Transepidermal waterloss, stratum corneum hydration and skin irritation were defined as target parameters. The application of the hydrophilic preparation and the hydrophilic vehicle led to a significant increase of the stratum corneum hydration. This results from the vehicle effect. There is no general recommendation to use topical applied sage extract to support the restitution of the human skin barrier.