Chemotherapy- induced peripheral neuropathy (CIPN) is a very common and burdening side effect of antineoplastic therapy in cancer patients. This dissertation, as a systematic review, is part of the S3- guideline "Supportive therapy in cancer patients". Therefore, treatment effects and quality of randomized controlled trials were graded and as far as possible pooled in meta- analyses. For none of the substances a recommendation regarding the prevention of CIPN could be given. For the therapy of CIPN duloxetine and considering the limited therapeutic options, amitryptiline, gabapentin and venlafaxine can be used. Since the quality of studies and treatment effects was very heterogeneous and methods of detecting CIPN varied largely, further high quality studies should be performed. On one hand, they should be aimed to find easy to perform and valid methods to detect CIPN and on the other hand to identify secure and effective agents to prevent and treat CIPN.