Tuberculosis is an worldwide problem whose resistance situation is worsening due to long and inadequately administered treatments. In the present work, known mechanisms of resistance were discussed and attempts were carried out to enable the re-use of established drugs by the synthesis of 48 novel 1,4-dihydropyridines (DHP). First, transporter-inhibiting properties on P-GP were examined, then the antimycobacterial activity was investigated alone and in combination with isoniazid, ethambutol, rifampicin, clofazimine and ciprofloxacin. In addition to growth inhibition in the laboratory germ GFP-H37Rv, which emanated from the DHP alone, also increases in the effectiveness of isoniazid, clofazimine and ciprofloxacin were detected. Due to the results of the P-GP essay, the inhibition of efflux pumps is considered to increase the effect, whereas specific target proteins could be postulated by comparsion with literature and protein databases.