Dendrimers are versatile synthetic highly branched polymers with well-defined molecular weight and the chemical composition of these compounds can be tailored, allowing predictable tuning of physical and chemical properties. As consequence of their unique behaviour, dendrimers are suitable for several industrial and biological applications. Quantum dots are nanocrystals with noteworthy optical, electrical, and mechanical properties that can be shaped to attend a desirable application. The traditional syntheses and surface functionalization of both macromolecules exhibit some challenges, including large number of reaction steps to achieve the desired features. With the purpose of eliminate such limitations, a new strategy based on isocyanide-based multicomponent reactions (IMCRs) can be developed. Herein, IMCRs are rationally applied for the divergent synthesis of dendrimers and for the surface functionalization of commercially available dendrimers and quantum dots. This strategy allows the addition of a new generation with multifunctional terminal groups and tuneable features, such as antimicrobial and anticancer properties.