The curious carbon cage structure of fullerenes, coupled with their unique chemical, physical and biological properties makes this class of compound valued assets in many research areas. To supply the demand of novel derivatives, just a few classical reactions offer products with good yields under mild conditions. Multicomponent reactions on the other hand, can add the desired diversity in the synthesis of fullerene derivatives, presenting an alternative pathway and boosting its applications in material and medical science. Looking to provide an efficient and versatile method for the decoration of fullerenes, herein its reported the first C60 derivatization strategy applying isocyanide-based multicomponent reactions, specifically the Passerini and Ugi reactions. Representative compounds were evaluated as photosensitizers for photodynamic activity showing promising results. Additionally, a new multicomponent process is described, generating fullereno derivatives with an unusual scaffold.