In this work a method for predicting the fatigue strength of multiaxial loaded elastomer components is developed. The method is based on the local SN curve concept, which essentially compares local stresses with material specific strength values. Measurement data are used to explore the elastomer specific nonlinear characteristics. On the one hand this affects the selection of suitable material models to simulate deformations and resulting local stresses. On the other hand fatigue strength parameters are determined and prepared for the fatigue simulation. Finally, investigations of engine and chassis mounts illustrate the applicability and verify the simulation method. The results show good agreement with both uni- and multiaxial load signals.