Ozone-depleting substances (ODS) have been used worldwide in a wide range of industrial and consumer applications. Their control under the Montreal Protocol has led to an uptake of alternatives, especially in refrigeration and air conditioning, as well as firefighting applications. Hydrofluorocarbons (HFCs) and other fluorinated gases – commonly referred to as F-gases – are among the most prominent ODS alternatives. These gases have no measurable effect on ozone depletion and now find widespread application. However, their high global warming potential (GWP) means that they are contributing to climate change and are therefore subject to the Kyoto Protocol under the United Nations Framework Convention on Climate Change (UNFCCC). This guidance document summarises the regulatory framework for both, ODS and F-gases, in the European Union (EU) and puts them into the Bulgarian context. New measures introduced by Regulation (EU) No. 517/2014, including the EU HFC phase-down and bans are highlighted. The document focuses on developing guidance and recommendations in regards to the implementation of both, the EU ODS and F-gas Regulations. Experience, also in other EU member states, is therefore referred to throughout the text. The goal of the document is to support Bulgaria in maximising its regulatory and enforcement capabilities with a focus on market surveillance and inspections of companies.