The most fundamental question which arises after tumornephrectomy is whether or not metastases will develop. In our investigations, we analysed HLA- class I and II alleles 2 detected in the 100 renal cell carcinoma patients (rcc) and those detected in the 24 metastatic rcc patients and compared them with individuals in the control group. Statistic analyses (c ²-test; Fisher’s-exact test) could not detect any significant deviation of HLA-class-I-alleles frequencies in the group of 100 rcc patients when compared with the control group. We, however, detected increases in HLA-class-II-alleles frequencies in HLA-DRB1*01 and -DQB1*05. 24 patients developed metastases. In this group we also noted increases in HLA-DQB1*05 frequency. HLA-A*31 and -Cw*04 were detected as increases too. Among mestastatic rcc patients an evident increase in HLA-DRB1*01 could no longer be detected as it initially was among the 100 rcc patients. An increase in DQBI*05 was detected in mestastatic rcc patients as well. We rechecked our results by analysing allelic combinations of two and three alleles. We also detected supplementary prognostic alleles. HLA-A*31, -A*32, -B*35, -Cw*04, -Cw*12, DRB1*01, -DRB1*15, -DQB1*05 and -DQB1*06 are alleles with prognostic classification factors for renal cell carcinomas and are useful for establishing a risk profile.