On the hand, this work aims at the isolation and characterization of candidate genes for hte disease,biochemical and electron microscopic investigation werde performed and mating experiments were set up to contribute to the understanding of the underlying pathogenetic mechanism. Differentia Display/Reverse Transkription PCR (DD/RT-PCR) was chosen as method for the isolatuion of potential candidate genes. Plasma activities of creatine kinase (CK) and lactate were detmined, respectively. Futhermore, sample of Musculus biceps femoris were comparatively analyzed by electron microscopy. Different mating combinations between healthy pigs and affected by the disease immediatly after birth should elucidate the mode of inheritance of congenital splay leg. Some of the identified genes (CDKN3, ATP 5I, BCL7B, TAF1B) were characterized as potential candidates for the syndrom. Significantly increased plasma levels for CK and LDH were obeserved in splay leg piglets at day 1 but not at other time. The results of this experiment support the hypothesis that congenital splay leg is a perinatal disturbance of the skeletal muscle development with properties of different myopathies.