In the present work was checked, whether for the TNFß-NcoI-SNP in the Intron 1, the faktor V Leiden gene variant and the Angiotensinogen-T174M-SNP an association can be proved to the coronary angiographic result at a Central German, purely Caucasian population (n = 660). Age-and sex paired samples were recruited with coronary angiographic secured results: a group of 95 coronary patients with at least 70 per cent narrowing of a main vessel and an illness age before the 56th year of life as well as a comparison group of 95 patients with coronary angiographic unobtrusive result. For the assessment of the frequency distributions of the checked genetic variants in the angiographic examined sample 470 unselected und anonymous long time blood donors of the same geographical region, also European Caucasians, were consulted. Results: The existence of CAD wasn't associated with the genotypes of the TNFß-NcoI SNP in the examined population in the Intron 1 (n = 463). A significant difference in the distribution of the genotypes and allele frequencys between the coronary patients and blood donors let an influencing through metabolic factors suspect. A tendency was found to increased appearance of the G-allele with an increasing markedness of CAD without significance. The TNFß-NcoI SNP had a significant lower serum cholesterol content for heterozygote allele carriers in the examined population. The Leiden mutation of the factor V (n = 644) and the Angiotensinogen-T174M-SNP (n = 640) weren't with the coronary angiographic result associated. However, was to record a protective tendency of the T-allele at the Angiotensinogen-T174M-Polymorphismus opposite the G-allele.