Recurrences of breast cancer after breast conserving therapy and irradiation are of importance for these patients. In this retrospective investigatin prognostic factors for disease free survival and local tumor control were analyzed. From 1996 until 2000 347 patients received adjuvant irradiation after breast conserving therapy. The median follow-up was 53,3 months (1 to 90 months). Survaval after 5 years was 93,5%. In 21 (6,1%) patients a locoregional recurrence occured. The 5-year-suvival probability for the disease-free-survival was 88,3%. Afrer 5 years 93,8% of women were without local recurrance. The median age of patients were 63 years. The univariate analysis according to the Cox regression method and according the Kaplan-Meier plot demonstrated significant results for the classical prognostig factors such as lymph node status, tumor size, age of patients on diagnosis and receptor status. Of prognostic importance were also tumor grading, menopausal status and kind of systemic therapy. Tumor grading and kind of systemic treatment played also a role for the local recurrence-free survival. The multivariate analysis according the Cox regression method demonstrated prognostic significance for local recurrence-free survival, age on diagnosis, lymph node status, tumor stage and kind of systemic therapy. For disease free survival the multivariate analysis revealed prognostic relevance of age, lymph node status, tumor stage and receptor status as well. This is not true for systemic therapy. The duration from time of diagnosis until beginning of irradiation is important for local tumor control and also for disease-free survival. It depends on kind of systemic therapy. The beginning of irrediation is prolonged due to adjuvant chemotherapy. In the multivariate Cox regression analysis the beginning of irradiation was of less importance than prognostic factors of tumor biology.