In the following article, a comprehensive gender-based retrospective analysis of angiologic patients at a university hospital is described (n=673). The study included all in-house patients diagnosed with PAD throughout a six-year period, comprising 461 men and 212 women (average ages 64,7 ± 10,1 and 70,1 ± 11,2 years, respectively, p < 0.001). PAD manifested 5 to 10 years later in women than in men. The stages of PAD, determined by FONTAINE and hemodynamic severity, showed no variation based on gender. Female patients with already existing diabetes mellitus demonstrated increased prevalence of symptomatic progression of PAD. Women primarily manifested distal PAD lesions, whereas proximal manifestation, including iliacal arteries, was dominant in men. Diabetes mellitus, as well as increased CRP and fibrinogen values, demonstrated a significant dominance among the risk factors for women. Women showed a higher tendency towards dyslipoproteinemia. Arterial hypertension was underrepresented in premenopausal women, a trend which reversed itself after the age of 60. Women demonstrated an increased tendency towards cerebrovascular events, while men primarily showed coronary comorbidity. Patients with previous histories of cardiovascular and/or cerebrovascular events had significantly higher homocysteine values than patients with isolated PAD. No significant gender-related differences were recognized in the treatment of PAD patients. However, there existed a tendency towards treating women less often with invasive therapies. A particular constellation of risks and manifestations of PAD were shown for female patients. In particular, female diabetics with PAD formed a high-risk group. Consideration of gender-based peculiarities in PAD is significant in the clinical treatment of patients with PAD.