The prostatic cancer is, in the meantime, the most frequent malignant neoplasm of men. Findings in PSA and/or digital-rectal examination cause the indication for prostate biopsy. The aim of prostate biopsy is to detect all patients with prostatic cancer. Also, it should give results to the grading and extension of the carcinoma in the prostate, in order to be able to select an adequate therapy for the individual patient. In this work, the histologic results of prostate biopsy and prostatectomy of 202 patients were compared with each other. All prostate biopsies as well as prostatectomies were performed at the Universitätsklinik und Polilinik für Urologie of the Martin-Luther-Universität Halle-Wittenberg. 87 patients received a sixfold biopsy of the peripheral zone of the prostate. 115 patients received a tenfold biopsy (6 biopsies of peripheral zone + 4 biopsies of transition zone). The value of both biopsy modes was compared with each other. In 9,6% of the patients with tenfold biopsy the tumor could be proved exclusively in the biopsies of the transition zone. Using the Helpap classification the tumor grading of the patients with tenfold biopsy agreed more often compared to the patients with sixfold biopsy. Using the Gleason classification no significant difference was shown. More than half of the patients had an undergrading in the biopsy. This was more frequent, the better the tumor differentiation in the biopsy histology was. Regarding the agreement of tumor extension (uni-vs. bilateral) in biopsies and prostatectomy specimens there was no difference between both biopsy methods. In 71% of the patients with an unilateral carcinoma in the biopsy histology, a bilateral carcinoma was found at the prostatectomy. A correspondence of the tumor extension could be ascertained in 45,5% of the cases.