Background: Nowadays, perforating keratoplasty ist one of the most frequently performed organ- respectively tissue-transplantation. Aim of this retrospective study was an analysis of data recovered from the Mitteldeutsche Corneabank Halle, a centre for perforating keratoplasty. An especial focus was directed on a possible rejection of the transplant subject to initial indication and risk-factors. Material and methods: Data of 100 patients, who had been treated with perforating keratoplasty during 1998-1999, was analysed. Patients could be divided into four groups, depending on their prognosis: group I: keratokonus, dystrophia as well as scarring of the cornea (n=43), group II: bullous keratoplasty (n=7), group III: ulceration and keratitis (n=14) and group IV: re-keratoplasty, trauma, acid-induced lesions and perforating trauma (n=36). Data analysis of the overall survival of transplant subject to initial indication was done by using the Kaplan-Meier-Method. Furthermore, impact of risk-factors on the performance of the transplant (i.e. size of transplant, vascularisation and synechia) as well as complications (i.e. complications due to elevated intraocular pressure endangering the transplant and insufficiency of suture), was taken into account. Results: The mean time of surveillance was 12,9 months (±10 months). A significantly difference in the overall survival of transplants was found beetween group I and IV (p=0,014). In group I, the one-year survival rate was 89% vs. 69% in group IV. Size of transplant (p=0,096), postoperative vascularisation (p=0,982) as well as variations in pressure (p=0,850) had no influence on prognosis or outcome. However, preoperative vascularisation had negative effects on the outcome (p=0,204; OR=2,2). Patients with synechia or insufficiency of sutures proved to have a significantly reduced overall survival of the transplant (p=0,001, OR=6,63; p=0,002, OR=7,182).